URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

Su, Shao-Hua; Wu, Yi-Fang; Lin, Qi

doi:10.1186/s12974-019-1668-0

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BioAcyl Corp

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Su, S.-H., Wu, Y.-F., & Lin, Q. (2019). URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion. Journal of Neuroinflammation, 16(1), 260.
Added by: Dr. Enrique Feoli (01/07/2023, 15:32) Last edited by: Dr. Enrique Feoli (01/07/2023, 15:33)

Resource type: Journal Article
DOI: 10.1186/s12974-019-1668-0
ID no. (ISBN etc.): 1742-2094
BibTeX citation key: Su2019
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Categories: BioAcyl Corp
Subcategories: Inflammasones
Creators: Lin, Su, Wu
Collection: Journal of Neuroinflammation

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Abstract

Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms underlying the CCH-induced abnormal excessive autophagy and neuroinflammation remain unknown. In this study, we investigated the roles of impaired autophagy in nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing (NLRP) 3 inflammasome activation in the rat hippocampus and the underlying mechanisms under the condition of induced CCH as well as the effect of URB treatment.