Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Luan, Harding H.; Medzhitov, Ruslan

doi:10.1016/j.cmet.2016.08.013

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BioAcyl Corp

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Luan, H. H., & Medzhitov, R. (2016). Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense. Cell Metab. 24(3), 379–387.
Added by: Dr. Enrique Feoli (03/02/2021, 02:02) Last edited by: Dr. Enrique Feoli (03/02/2021, 02:04)

Resource type: Journal Article
DOI: 10.1016/j.cmet.2016.08.013
ID no. (ISBN etc.): 1550-4131
BibTeX citation key: Luan2016
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Categories: BioAcyl Corp
Subcategories: Autacoides
Creators: Luan, Medzhitov
Collection: Cell Metab.

Views: 2/194

Abstract

Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.