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Schett, G., & Neurath, M. F. (2018). Resolution of chronic inflammatory disease: universal and tissue-specific concepts. Nat. Commun. 9(3261), 1–8. Added by: Dr. Enrique Feoli (12/02/2021, 19:11) Last edited by: Dr. Enrique Feoli (12/02/2021, 19:16) |
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| Resource type: Journal Article Published DOI: 10.1038/s41467-018-05800-6 ID no. (ISBN etc.): 2041-1723 BibTeX citation key: Schett2018 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inflammation resolution Creators: Neurath, Schett Collection: Nat. Commun. |
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| Abstract |
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Inflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss the resolution of inflammation in both a biological and translational context. We introduce the concept of impaired resolution leading to diseases like rheumatoid arthritis, Crohn's disease, and asthma, as well as the cellular and molecular components that contribute to resolution of joint, gut, and lung inflammation, respectively. Finally, we discuss potential intervention strategies for fostering the resolution process, and their implications for the therapy of inflammatory diseases.
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| Notes |
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Activation, resolution, and the process leading to chronicity of inflammation. Time course of the inflammatory response with activation phase, peak phase, and resolution phase. Failure of resolution leads to chronic inflammatory diseases. Key cells of the activation and resolution phase are shown in the gray squares. ILC innate lymphoid cells, TH17 T helper cells 17, MΦ macrophages
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
