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Okabe, Y., & Medzhitov, R. (2014). Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages. Cell, 157(4), 832–844. Added by: Dr. Enrique Feoli (20/02/2021, 02:24) Last edited by: Dr. Enrique Feoli (20/02/2021, 02:25) |
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| Resource type: Journal Article DOI: 10.1016/j.cell.2014.04.016 ID no. (ISBN etc.): 0092-8674 BibTeX citation key: Okabe2014 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inflammation resolution Creators: Medzhitov, Okabe Collection: Cell |
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| Abstract |
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Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals.
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