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Sedlic, F., & Kovac, Z. (2017). Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits. Redox Biology, 13, 235. Added by: Dr. Enrique Feoli (26/05/2022, 12:40) Last edited by: Dr. Enrique Feoli (26/05/2022, 12:44) |
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| Resource type: Journal Article DOI: 10.1016/j.redox.2017.05.008 BibTeX citation key: Sedlic2017 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Stress response Creators: Kovac, Sedlic Collection: Redox Biology |
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| Abstract |
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Finite disarrangements of important (vital) physiological agents and nutrients can induce plethora of beneficial effects, exceeding mere attenuation of the specific stress. Such response to disrupted homeostasis appears to be universally conserved among species. The underlying mechanism of improved fitness and longevity, when physiological agents act outside their normal range is similar to hormesis, a phenomenon whereby toxins elicit beneficial effects at low doses. Due to similarity with such non-linear response to toxins described with J-shaped curve, we have coined a new term “mirror J-shaped curves” for non-linear response to finite disarrangement of physiological agents. Examples from the clinical trials and basic research are provided, along with the unifying mechanisms that tie classical non-linear response to toxins with the non-linear response to physiological agents (glucose, oxygen, osmolarity, thermal energy, calcium, body mass, calorie intake and exercise). Reactive oxygen species and cytosolic calcium seem to be common triggers of signaling pathways that result in these beneficial effects. Awareness of such phenomena and exploring underlying mechanisms can help physicians in their everyday practice. It can also benefit researchers when designing studies and interpreting growing number of scientific data showing non-linear responses to physiological agents.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
Hormetic dose-response curves. (A) Typical J-shaped curve of hormesis induced by toxic agents. At low doses some toxins exhibit beneficial effects (green), while detrimental effects (red) occur at high doses. (B) Physiological agents induce hormesis-like response when acting outside their physiological range, as shown by the proposed mirror J-shaped curves. At slightly lower or higher doses than the normal range (green), physiological agents trigger response that produces beneficial effect that exceeds sole adaptation to the stress and produces broader positive effects, such as increased functional capacity and/or fitness. A greater deviation from the physiological range harms the cell/organism. Altogether this represents a non-linear response. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)Publisher: Elsevier Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |