Role of macrophage autophagy in postoperative pain and inflammation in mice

Mitsui, Kazuha; Hishiyama, Sohei; Jain, Aakanksha

doi:10.1186/s12974-023-02795-w

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BioAcyl Corp

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Mitsui, K., Hishiyama, S., & Jain, A. (2023). Role of macrophage autophagy in postoperative pain and inflammation in mice. Journal of Neuroinflammation, 20(1), 102.
Added by: Dr. Enrique Feoli (26/05/2023, 18:39) Last edited by: Dr. Enrique Feoli (26/05/2023, 18:39)

Resource type: Journal Article
DOI: 10.1186/s12974-023-02795-w
ID no. (ISBN etc.): 1742-2094
BibTeX citation key: Mitsui2023
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Categories: BioAcyl Corp
Subcategories: Autophagy and mitophagy
Creators: Hishiyama, Jain, Mitsui
Collection: Journal of Neuroinflammation

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Abstract

Postoperative pain and inflammation are significant complications following surgery. Strategies that aim to prevent excessive inflammation without hampering natural wound-healing are required for the management of postoperative pain and inflammation. However, the knowledge of the mechanisms and target pathways involved in these processes is lacking. Recent studies have revealed that autophagy in macrophages sequesters pro-inflammatory mediators, and it is therefore being recognized as a crucial process involved in regulating inflammation. In this study, we tested the hypothesis that autophagy in macrophages plays protective roles against postoperative pain and inflammation and investigated the underlying mechanisms.