BioAcyl Corp |
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| Resource type: Journal Article DOI: 10.1126/sciimmunol.aag0479 ID no. (ISBN etc.): 2470-9468 BibTeX citation key: Pradeu2016 View all bibliographic details |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Immunological memory, Microbiota on immunity Creators: Pradeu, Vivier Collection: Science Immunology |
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| Abstract |
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Some biological systems detect the rate of change in a stimulus rather than the stimulus itself only. We suggest that the immune system works in this way. According to the discontinuity theory of immunity, the immune system responds to sudden changes in antigenic stimulation and is rendered tolerant by slow or continuous stimulation. This basic principle, which is supported by recent data on immune checkpoints in viral infections, cancers, and allergies, can be seen as a unifying framework for diverse immune responses.
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