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Pradeu, T., & Vivier, E. (2016). The discontinuity theory of immunity. Science Immunology, 1(1), AAG0479. 
Added by: Dr. Enrique Feoli (31/08/2025, 17:45)   Last edited by: Dr. Enrique Feoli (31/08/2025, 17:46)
Resource type: Journal Article
DOI: 10.1126/sciimmunol.aag0479
ID no. (ISBN etc.): 2470-9468
BibTeX citation key: Pradeu2016
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 Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Immunological memory, Microbiota on immunity
Creators: Pradeu, Vivier
Collection: Science Immunology		 Views: 1/13
Abstract
Some biological systems detect the rate of change in a stimulus rather than the stimulus itself only. We suggest that the immune system works in this way. According to the discontinuity theory of immunity, the immune system responds to sudden changes in antigenic stimulation and is rendered tolerant by slow or continuous stimulation. This basic principle, which is supported by recent data on immune checkpoints in viral infections, cancers, and allergies, can be seen as a unifying framework for diverse immune responses.
  
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