NRF2 signalling in cytoprotection and metabolism

Murakami, Shohei; Kusano, Yusuke; Okazaki, Keito

doi:10.1111/bph.16246

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BioAcyl Corp

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Murakami, S., Kusano, Y., & Okazaki, K. Nrf2 signalling in cytoprotection and metabolism. British Journal of Pharmacology, n/a(n/a).
Added by: Dr. Enrique Feoli (08/11/2025, 23:57) Last edited by: Dr. Enrique Feoli (09/11/2025, 00:02)

Resource type: Journal Article
DOI: 10.1111/bph.16246
BibTeX citation key: Murakami
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Categories: BioAcyl Corp, BioAcyl Corp
Subcategories: Cell injury cytoprotection, Nrf2 signaling
Keywords: antioxidant, Metabolism, Mitochondria, supersulfide
Creators: Kusano, Murakami, Okazaki
Collection: British Journal of Pharmacology

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Abstract

The KEAP1-NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1-NRF2 system has been regarded as a sulfur-utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur-mediated redox reactions. NRF2 is a key regulator of cytoprotective genes, such as antioxidant and detoxification genes, and also possesses potent anti-inflammatory activity. Recently NRF2 has been the focus of attention as a regulator of cellular metabolism and mitochondrial function. The NRF2-mediated regulatory mechanisms of metabolites and mitochondria have been considered diverse, but have not yet been fully clarified. This review article provides an overview of molecular mechanisms that regulate NRF2 signalling and its cytoprotective roles, and highlights NRF2 contribution to cellular metabolism, particularly in the context of mitochondrial function and newly-found sulfur metabolism.

Notes

Details are in the caption following the image

Sulfur metabolism in mitochondria. Flow of sulfur metabolites in cells and mitochondria is shown with the responsible enzymes for each step. Enzymes involved in the supersulfide production and sulfur oxidation pathway are shown in blue and green, respectively. I, II, III, and IV indicate complexes in electron transport chain. Q and QH2 indicate ubiquinone and ubiquinol, respectively.

Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli