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Chandrasekaran, A., Idelchik, M. D. P. S., & Melendez, A. J. (2017). Redox control of senescence and age-related disease. Redox Biology, 11, 91–102. Added by: Dr. Enrique Feoli (16/06/2020, 02:32) |
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| Resource type: Journal Article DOI: 10.1016/J.REDOX.2016.11.005 ID no. (ISBN etc.): 2213-2317 BibTeX citation key: Chandrasekaran2017 View all bibliographic details  |
Categories: Mendeley, Mendeley Subcategories: Bioregulatory systems medicine Creators: Chandrasekaran, Idelchik, Melendez Collection: Redox Biology |
Views: 5/271
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| Abstract |
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The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades. While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases. Finally, we discuss progress in designing therapeutic strategies that manipulate the cellular redox environment to restrict age-associated pathology.
Added by: Dr. Enrique Feoli |