BioAcyl Corp
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Kundu, R., Narean, J. S., Wang, L., & others. (2022). Ccl2-ccr2 signaling in disease pathogenesis. Nat. Commun. 15(2), 1–8. Added by: Dr. Enrique Feoli (11/01/2022, 07:50) Last edited by: Dr. Enrique Feoli (11/01/2022, 07:53) |
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| Resource type: Journal Article Published DOI: 10.2174/1871530315666150316120920 ID no. (ISBN etc.): 2212-3873 BibTeX citation key: OConnor2015 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Chemokines Creators: Kundu, Narean, others, Wang Collection: Nat. Commun. |
Views: 21/303
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| Abstract |
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Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p{hspace{0.167em}}={hspace{0.167em}}0.0139), and nucleocapsid-specific (p{hspace{0.167em}}={hspace{0.167em}}0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n{hspace{0.167em}}={hspace{0.167em}}26), when compared with those who convert to PCR-positive (n{hspace{0.167em}}={hspace{0.167em}}26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-na{ifmmodeddot{imath}else"{i}fi}ve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
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