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Pal, S., & Tyler, J. K. (2016). Epigenetics and aging. Science Advances, 2(7), e1600584. Added by: Dr. Enrique Feoli (03/05/2023, 19:02) Last edited by: Dr. Enrique Feoli (03/05/2023, 19:09) |
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| Resource type: Journal Article DOI: 10.1126/sciadv.1600584 BibTeX citation key: Pal2016 View all bibliographic details  |
Categories: BioAcyl Corp, BioAcyl Corp Subcategories: Ageing, Epigenetics and immune response Creators: Pal, Tyler Collection: Science Advances |
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| Abstract |
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Researchers review how random changes and our environment (for example, diet) determines our life span. Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic changes occur at various levels, including reduced bulk levels of the core histones, altered patterns of histone posttranslational modifications and DNA methylation, replacement of canonical histones with histone variants, and altered noncoding RNA expression, during both organismal aging and replicative senescence. The end result of epigenetic changes during aging is altered local accessibility to the genetic material, leading to aberrant gene expression, reactivation of transposable elements, and genomic instability. Strikingly, certain types of epigenetic information can function in a transgenerational manner to influence the life span of the offspring. Several important conclusions emerge from these studies: rather than being genetically predetermined, our life span is largely epigenetically determined; diet and other environmental influences can influence our life span by changing the epigenetic information; and inhibitors of epigenetic enzymes can influence life span of model organisms. These new findings provide better understanding of the mechanisms involved in aging. Given the reversible nature of epigenetic information, these studies highlight exciting avenues for therapeutic intervention in aging and age-associated diseases, including cancer.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
The pink writing refers to dietary, chemical, or therapeutic interventions that can extend life span, in at least some organisms (described in the text). Arrows indicate stimulating effects, and blocked lines indicate inhibitory effects. This schematic is not meant to be exhaustive but highlights the pathways that alter the epigenetic information and autophagy. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |